Guides / PDRN
PDRN
PDRN (polydeoxyribonucleotide) is a DNA-fragment active used for recovery-focused skincare. This guide explains what it is, where it comes from, and how to select a grade with intention.
What it is
PDRN is a mixture of deoxyribonucleotide chains, typically sourced from purified fish DNA. In topical and injectable aesthetics contexts it is valued for supporting tissue repair signaling rather than acting as a classic humectant or oil.
Formulation notes
Look for molecular-weight ranges, purity documentation, and recommended use levels from the supplier. PDRN is usually water-soluble and pairs with calming, barrier-support systems rather than aggressive peels.
Selection checklist
Confirm origin, sterilization or purification claims, INCI naming, and whether the grade is intended for leave-on skincare versus professional use only.